Telomeres
A series of hyperbaric sessions induces adaptive cellular responses that activate regenerative processes. A clinical study found telomere lengthening of more than 20% after 60 sessions at 2.0 ATA.
Longevity & biohacking
HBOT as a tool for biological optimisation.
The best investment in health is not the one that fixes a problem. It is the one that moves biological limits. HBOT triggers processes at the cellular level that other interventions do not reach. Here is the data.
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What HBOT does at the cellular level
Repeated series of hyperbaric therapy produce physiological changes that go beyond a simple rise in oxygen saturation. The mechanisms relevant to longevity and biological optimisation:
Senescent cells
The same study recorded a marked reduction in the concentration of senescent T cells. Senescence is one of the main “hallmarks of aging” and reducing it is a direct target of longevity protocols.
Mitochondrial function
HBOT stimulates mitochondrial biogenesis and increases ATP production, the primary source of cellular energy. Mitochondrial capacity is a key predictor of biological age and performance.
Angiogenesis
A rise in VEGF (vascular endothelial growth factor) supports the formation of new blood vessels and improves microcirculation. Bryan Johnson recorded a 300% increase in VEGF after a series of 60 sessions.
Oxidative stress
Paradoxically, the temporary rise in oxidative stress during HBOT activates the body’s own antioxidant systems. The result is reduced chronic inflammation and improved cellular resilience.
Stem cells
HBOT stimulates the production and proliferation of stem cells, which supports tissue renewal and regeneration. The effect has been documented in clinical settings and is part of protocols for neurological rehabilitation.
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The key study: Dr Shai Efrati, 2020
A study published in the journal Aging in 2020 followed healthy adults who completed 60 sessions of hyperbaric therapy at 2.0 ATA. Results measured in peripheral blood cells:
20–38%
Telomere lengthening
T-helper, T-cytotoxic, NK and B cells
up to 37%
Drop in senescent cells
T-helper senescent cells after HBOT
60
Protocol sessions
5× a week for 12 weeks
2.0 ATA
Pressure protocol
Clinical specification of the study
Telomere lengthening of 20–38% is one of the strongest results recorded so far for a non-pharmacological intervention in the peer-reviewed literature. Telomeres are a direct indicator of cellular age.
Efrati S. et al. Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells: a prospective trial. Aging, vol. 12, no. 22, 2020, pp. 22445–22456.
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The same technology Bryan Johnson uses. The protocol is available in Prague.
Bryan Johnson, the founder of the Blueprint protocol, completed 60 HBOT sessions in 90 days at a pressure of 2.0 ATA. It was part of the most thoroughly documented self-experiment in the history of biohacking. His results are an N=1 self-experiment, not a randomised controlled trial. The clinical evidence comes from Dr Efrati’s study above. It remains an interesting data point.
- Founder of Blueprint. He sold Braintree to PayPal for USD 800 million. He invests USD 2 million a year in biological optimisation.
- A 300% rise in VEGF, better muscle oxygenation during exercise and positive changes in the epigenetic profile.
- Johnson’s chamber is made by HpoTech. Our Giza chamber is the four-person version from the same manufacturer: the same technology, the same certifications.
- For the longevity protocol at 2.0 ATA we have full capacity, with no compromises.
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Technology matters. The difference shows in the results.
A hard-shell chamber. Clinical pressure. The same manufacturer as Johnson’s chamber.
As the only private practice in Prague we offer genuine HBOT at up to 2.4 ATA in a hard-shell chamber with a BIBS mask. We have full capacity for the longevity protocol at 2.0 ATA as described in Dr Efrati’s study.
Maximum pressure
2.4 ATA
The level used in clinical settings. Other private providers in the Czech Republic reach 1.5 ATA at most.
Oxygen delivery system
BIBS
The only standard in serious hyperbaric therapy. Maximum oxygen concentration in every breath. No dilution, exactly where it belongs.
Oxygen purity
94%+
A professional oxygen station with filtration. Consistent values in every session.
Parameter
Wellness HBOT chambers
Kyslíková terapie Praha
Maximum pressure
1.3–1.5 ATA
Up to 2.4 ATA
Oxygen delivery
Nasal cannula, oxygen diluted by chamber air
BIBS mask. No dilution, pure oxygen in every breath.
Oxygen source
Portable generator
Professional oxygen station with filtration
Oxygen purity
40–60%
Consistently 94%+
Comfort and space
Single-person capsule, narrow entry
Spacious chamber for four people, comfortable seats
Why a cannula (oxygen prongs) is not enough.
With a nasal cannula the client exhales back into the chamber. The exhaled air mixes with the oxygen from the cannula, raises the oxygen concentration inside the closed space above a safe level and at the same time markedly lowers the purity of what the client breathes in. BIBS is a closed system that carries exhaled air entirely out of the chamber, so every breath contains pure oxygen without dilution.
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Our space and the chamber
The HPO Giza chamber in central Prague. Rigid construction, clinical pressure up to 2.4 ATA, a spacious interior for four people. Click to enlarge.
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The Efrati longevity protocol
The protocol follows Dr Efrati’s study: 60 sessions at 2.0 ATA. We offer two variants — the full protocol exactly as in the study, or a first series with the option to continue.
Recommended
Full protocol
Exactly as in Dr Efrati’s study
- Sessions
- 60
- Pressure protocol
- 2.0 ATA
- Session length
- 90 minutes
- Frequency
- 3–5× a week
CZK 55,000
First series
An entry point with the option to continue
- Sessions
- 30
- Pressure protocol
- 2.0 ATA
- Session length
- 90 minutes
- Frequency
- 3–5× a week
CZK 30,000
Hyperbaric oxygen therapy pricing
- Hyperbaric oxygen therapy — 1 sessionCZK 1,600
- Hyperbaric oxygen therapy — 5 sessions An ideal first experience of hyperbaric oxygen therapyCZK 7,000
- Hyperbaric oxygen therapy — 10 sessions Most popular package for energy and recovery supportCZK 12,000
- Hyperbaric oxygen therapy — 20 sessions For clients who want systematic support for performance and vitalityCZK 22,000
The Efrati protocol prices apply to the complete series as described in the study. The price of the first series counts towards the price of the full protocol. We set the schedule and frequency individually at the free initial consultation. The table above lists prices for single hyperbaric oxygen therapy sessions and packages outside the protocol.
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The people who come to us
Google reviews, translated from Czech.
“After only a few hyperbaric oxygen therapy sessions I noticed more energy, better concentration and a better overall physical and mental state.”
“I can only recommend the oxygen therapy here. The team is friendly and the place feels welcoming. After the sessions I feel full of energy.”
“After a single oxygen therapy session my post-operative scar looked completely different. I could not believe my own eyes. The team were very kind and professional.”
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An easy-to-reach clinic in central Prague
You will find us a few steps from the I. P. Pavlova metro station. Easy to reach by car, public transport or on foot.
- Appointments right away, even the next day. No waiting list.
- Parking is easy — on the street or in the nearby garages.
- Public transport: I. P. Pavlova metro station (line C); trams 6, 11 and 22.
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Not sure whether the therapy is right for you?
Get in touch. We’ll go through what you are dealing with and recommend the best next step. No pressure, no overpromising.
Opening hours: Mon–Fri 9am–7pm
Message us on WhatsApp any time. We’ll reply as soon as we can.11
Frequently asked questions
Can I combine HBOT with other longevity protocols?
Yes. HBOT combines well with other protocols such as intermittent fasting, cold exposure or NAD+ supplementation. There are synergies in particular with protocols that activate mitochondrial biogenesis. We recommend discussing the timing of sessions in the context of your overall protocol.
What is the difference between the full protocol and the first series in terms of results?
The clinical evidence for telomeres comes from 60 sessions. The first series is an entry point where you get the first measurable data and a subjective sense of the effect. The results of the first series will tell you how your body responds to the protocol and whether you want to continue to the full course.
Can I continue to the full protocol after the first series?
Yes. The first series is designed precisely as an entry point with the option to continue. If you decide to continue after 30 sessions, we pick up directly from the first series without interrupting the protocol. The price of the first series counts towards the price of the full course.
How should I measure the results?
The simplest approach is to track energy, sleep and performance subjectively. If you want data, we recommend biological markers before and after the series: telomere length, CRP, a full blood count and optionally epigenetic tests such as TruAge or the Horvath clock. You arrange these tests yourself through a laboratory or a longevity clinic.
Is HBOT safe at an intensity of 3 to 5 sessions a week?
Yes. The protocol follows a clinical study that worked with a frequency of 5× a week. Before you start we carry out an initial consultation to rule out contraindications. We adjust the frequency individually within a range of 3 to 5 sessions a week.